Branch-restricted localization of phosphatase Prl-1 specifies axonal synaptogenesis domains

Autor:	Sonja Sachse, Olivier Urwyler, Sofie Vandenbogaerde, Anke Misbaer, Dietmar Schmucker, Azadeh Izadifar
Rok vydání:	2019
Předmět:	Messenger RNA Multidisciplinary biology Phosphatase Synaptogenesis Cell biology Synapse Insulin receptor medicine.anatomical_structure biology.protein medicine Compartment (development) Axon Signal transduction
Zdroj:	Science. 364
ISSN:	1095-9203 0036-8075
Popis:	Compartmentalization of axons Neurons can spread branches far and wide across the central nervous system. One neuron can simultaneously contact several other neurons, amplifying network complexity. Studying the Drosophila brain, Urwyler et al. found that not all axon branches are the same, even within one neuron (see the Perspective by Falkner and Scheiffele). A membrane-anchored phosphatase functions within a subset of axon branches to regulate synapse formation. Thus, the pattern of synapses on one neuron is not random but rather is spatially restricted according to subcompartments in the axon. Science , this issue p. eaau9952 ; see also p. 437
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9a9006e1915981e1b4f170999f6ef16f https://doi.org/10.1126/science.aau9952 Zobrazit plný text záznamu