The potential of Tamarindus indica seed extract as anti-snake venom against Ophiophagus hannah, Naja kaouthia and Daboia russelli in mice
| Autor: | Khin Maung Maung, Pakeer Oothuman Syed Ahamed, Soraya Ismail |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
biology
Traditional medicine business.industry animal diseases Phosphomonoesterase Venom General Medicine Anti snake venom biology.organism_classification complex mixtures nervous system diseases Phospholipase A2 Snake venom Toxicity biology.protein TAMARINDUS INDICA SEED Naja kaouthia Medicine business |
| Zdroj: | IIUM Medical Journal Malaysia. 15 |
| ISSN: | 2735-2285 1823-4631 |
| Popis: | Introduction: Globally, snakebite cases are estimated to be around 5 million annually affecting mainly the poorer countries like Africa and Asia, and in 2009 WHO has categorized it as a ‘neglected tropical disease’. Currently the standard treatment for snake envenomation is the anti-snake venom therapy, which is expensive, poor supply and species specific. This study was conducted to evaluate the potential of using Tamarindus indica seed extract (TSE) to inhibit the in-vitro and in-vivo effects of snake venom of three snakes; namely Ophiophagus hannah, Naja kaouthia and Daboia russelli. Methods: Methanolic extract of TSE was used. In-vitro enzymatic inhibition study i.e phospholipase A2, proteolytic and phosphomonoesterase were studied. In-vivo acute subcutaneous (SC) toxicity of TSE in ICR mice was conducted. Study on the SC TSE inhibition of lethality was also conducted. Results: Findings from enzymatic inhibition studies showed that, TSE was able to significantly reduce (p |
| Databáze: | OpenAIRE |
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