Evaluation of genetic susceptibility of six type II diabetes Genome-Wide association tudies loci for obesity

Autor: Yehia M. Shaker, Esmat Ashour, Lamiaa Mageed, Waleed Hamimy, Weaam Gouda, Mie Afify
Rok vydání: 2020
Předmět:
Zdroj: Meta Gene. 26:100758
ISSN: 2214-5400
1686-1329
Popis: Background Obesity is heritable and is known to predispose to many diseases. Obesity is considered as a complex or multifactorial condition that is associated with complicated interplay between genetic and non-genetic factors. Genetic factors play an indispensable role in the individual's predisposition to obesity. Objective To conduct a genome-wide association study, to determine the relation between obesity and adiposity and different diabetes GWAS loci, by analysing the effect of six different types namely, rs3923113 (GRB14), rs16861329 (ST6GAL1), rs1802295 (VPS26A), rs7178572 (HMG20A), rs2028299 (AP3S2) and rs4812829 (HNF4A) on obesity. Subjects and methods This observational study included 456 subjects (obese = 300, controls = 156), who were genotyped by TaqMan assay and their biochemical parameters were determined. The frequencies of their genotypes were calculated and their association with obesity and lipid profile were analyzed. Results A significant association was found between the dominant model of rs 3,923,113 (GRB14; P = .05), dominant model of rs 1,802,295 (VPS26A; P = .03), co-dominant and recessive models of rs 2,028,299 (APsS2; P = .001 & P = .000), respectively; and co-dominant, dominant and recessive models of rs 4,812,829 (HNf4A; P = .000) polymorphisms and the risk of obesity, whereas there was no association for both rs 16,861,329 (ST6GAL1) and rs 7,178,572 (HMG20A) of six type II diabetes GWAS. Conclusion SNPsrs2028299 (AP3S2) and rs4812829 (HNF4A) are significantly associated with obesity.
Databáze: OpenAIRE
Externí odkaz: