| Autor: |
S. Birkos, Jane Kearns, George D. Montoya, M. McKeen, Jin Wu, D. Feldman, Thomas M. Williams, Malek Kamoun, S. Bassinger |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Tissue Antigens. 59:426-429 |
| ISSN: |
0001-2815 |
| DOI: |
10.1034/j.1399-0039.2002.590512.x |
| Popis: |
Sequence specific oligonucleotide probe hybridization and sequence specific primer PCR typing of volunteer bone marrow donors suggested the presence of variants of known HLA-B alleles in two individuals. PCR products encompassing HLA-B locus exons 1, 2, and 3 were prepared, subcloned and sequenced. A Hispanic individual had a novel B*07 allele (B*0714) and a Chinese individual had a novel B*27 allele (B*2718). In two other individuals, a previously unknown sequence of exon 1 was determined for HLA-B*0709 (African American) and B*2714 (Native American). These findings further illustrate the substantial genetic variation present at the HLA-B locus within human populations. We discuss the structural variation in the protein sequence for these HLA-B alleles and its potential functional effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
