Biochemical and Histopathological effects of Acetaminophen and Protective Effects of Naringin on Liver Rats
| Autor: | Aryaf Mahmood Sabea, Bashar Sabah Sahib, Jawad Kadhim Faris, Ahlam J. H. AlKhamas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
biology Bilirubin Health Toxicology and Mutagenesis medicine.medical_treatment Albumin Toxicology Malondialdehyde Pathology and Forensic Medicine Acetaminophen chemistry.chemical_compound Endocrinology chemistry Alanine transaminase Internal medicine medicine biology.protein Alkaline phosphatase Law Naringin Saline medicine.drug |
| Zdroj: | Indian Journal of Forensic Medicine & Toxicology. |
| ISSN: | 0973-9122 |
| DOI: | 10.37506/ijfmt.v15i4.16801 |
| Popis: | This study was conducted to find out liver protective activity of naringin (NRG) 40-80 mg/kg body weight(b.w.) against acetaminophen (ACN) 2g/kg induced liver damage in rats. Thirty two male rats were dividedinto four groups : group1: negative control, (1 ml/kg Saline orally) group II: positive control ACN (2g/kg), orally as single dose at first day, group III: ACN (2g/kg), orally as single dose at first day , plus NRG(40 mg//kg) orally for (8) consecutive days, group IV: ACN (2g/kg), orally as single dose at first day , plusNRG (80 mg//kg) orally for (8) consecutive days. All the rats were anesthetized to collect blood then killedon the (9) day of the experiment to take the liver samples. ACN induced liver damage was proved by asignificant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|