| Autor: |
C. R. Mote, E. J. Deming, L. N. D. Potgieter, R. D. von Bernuth |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Journal of Environmental Science and Health . Part A: Environmental Science and Engineering and Toxicology. 27:2199-2211 |
| ISSN: |
1077-1204 |
| DOI: |
10.1080/10934529209375849 |
| Popis: |
A study was initiated to evaluate the feasibility of using pigs as an animal model to assess the risk of human viral infection from land application of treated wastewater. The model system consisted of three‐week‐old pigs and porcine enterovirus‐serotype 2 (PE2). Pigs were used because the porcine digestive tract and porcine enterovirus infections in pigs are similar to that of man. An oral challenge inoculation experiment was carried out to examine antibody production in pigs as a result of PE2 virus infection. Piglets free of antibody were intragastrically inoculated with 0, 100 or 100,000 CCID50 (50% cell culture infective dose) of PE2 virus. Serum was monitored to detect antibody to PE2 virus at 3, 7, 10 and 13 days post inoculation. By 13 days post inoculation all pigs challenge inoculated with as little as 100 CCID50 of PE2 virus had seroconverted. To evaluate the potential for using pigs to assess the risk of viral infection from contact with virus on lawns, piglets free of antibody to PE2... |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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