A New Pharmacophore of Potential Antimycobacterial Activity: The Disulfide Group in the Ring of Alicyclic Compounds

Autor:	Karel Waisser, Hans-Dietrich Stachel, Želmíra Odlerová
Rok vydání:	1997
Předmět:	chemistry.chemical_classification biology Chemistry Stereochemistry medicine.drug_class Disulfide bond General Chemistry biology.organism_classification Ring (chemistry) Antimycobacterial Disulfide group Mycobacterium tuberculosis Alicyclic compound medicine Moiety Pharmacophore
Zdroj:	Collection of Czechoslovak Chemical Communications. 62:510-515
ISSN:	1212-6950 0010-0765
DOI:	10.1135/cccc19970510
Popis:	A series of thirty 2,3-dithiabicyclo[3.3.0]octa-4,8-diene derivatives was examined for antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. avium, and M. fortuitum. The structure-activity relationships were analysed by Free-Wilson method. The authors consider the disulfide moiety to be the pharmacophore of antimycobacterial activity. To verify the idea, several other monocyclic sulfides, 3,4-dihydro-1,2-dithiolane derivatives, were also evaluated.
Databáze:	OpenAIRE
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