Association of Subclinical Coronary Artery Disease and Ischemic Stroke Caused by Cervical or Intracranial Atherosclerosis
| Autor: | Carlos Andre Oshiro, Roberto Nery Dantas Junior, Ana Luíza Vieira de Araújo, Gisele Sampaio Silva, Claudia da Costa Leite, Edson Bor Seng Shu, Maramélia Miranda Alves, Adriana Bastos Conforto, Victor Marinho Silva, Raul Dias dos Santos Filho, Cesar Higa Nomura, Marcelo de Lima Oliveira, Márcio Sommer Bittencourt, María M. Martín |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis business.industry Intracranial Artery General Medicine medicine.disease Coronary Calcium Score Coronary artery disease Stenosis Internal medicine Cardiology Medicine cardiovascular diseases business Stroke Coronary atherosclerosis Subclinical infection |
| Zdroj: | Cardiology and Cardiovascular Medicine. |
| ISSN: | 2572-9292 |
| Popis: | Background: Coronary calcium score (CAC) is a marker of coronary atherosclerosis. We compared CAC scores in patients with ischemic stroke (IS) caused by large-artery atherosclerosis (Groupathero) to a control group (Groupcontrol), in multiethnic subjects without history of symptomatic coronary artery disease (CAD). Methods: In this cross-sectional study, subjects in Groupathero (n=80) had at least one symptomatic stenosis ≥ 50% in the carotid or vertebrobasilar territories. Groupathero included two subgroups: stenosis in either cervical or intracranial arteries (GroupExtraorIntra), and in at least one cervical and one intracranial artery (GroupExtra&Intra). Subjects in Groupcontrol (n=40) had no history of stroke or stenosis ≥ 50% in cervical or intracranial arteries. Frequencies of CAC ≥ 100 and CAC > 0 were compared between the groups and subgroups by bivariate logistic regressions. Multivariate analyses were also performed. Results: Rates of CAC ≥ 100 were not significantly different between Groupathero and Groupcontrol but were significantly greater in GroupExtraI 1.21-18.04; p = 0.025). CAC > 0 was significantly more frequent in Groupathero (85%) than Groupcontrol (OR, 4.19; 1.74-10.07; p = 0,001). In multivariate analyses, “Groupathero” and “GroupExtra&Intra” was significantly and independently associated with CAC. Conclusions: The frequency of coronary calcification was higher in subjects with atherothrombotic stroke without symptoms of coronary disease than in controls with similar vascular risk factors. In patients with stroke, the burden of subclinical CAD was significantly higher in those with cervical and intracranial atherosclerosis. |
| Databáze: | OpenAIRE |
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