Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms

Autor:	Selin Özkan-Kotiloğlu, Dilek Kaya-Akyüzlü, Rabia Yurdakul, Mukaddes Asena Yıldırım, İnci Özgür-İlhan
Rok vydání:	2023
Předmět:	General Medicine
Zdroj:	Alcohol and Alcoholism.
ISSN:	1464-3502 0735-0414
DOI:	10.1093/alcalc/agad036
Popis:	Aims: The dynorphin (DYN)/Kappa Opioid Receptor (KOR) system has been suggested to be involved in both negative affective states and the action of alcohol. The present study was undertaken to explore whether the DYN/KOR system genes, PDYN and OPRK1, influence on individual differences in the intensity of depressive symptoms at admission as well as the risk of alcohol use disorder (AUD) risk in a sample of 101 individuals with AUD and 100 controls. Methods: PDYN (rs2281285, rs2225749 and rs910080) and OPRK1 (rs6473797, rs963549 and rs997917) polymorphisms were analyzed by PCR-RFLP. The intensity of depressive and anxiety symptoms and craving were measured by the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and Penn Alcohol Craving Scale, respectively. Results: A significant association between the risk of AUD and OPRK1 rs6473797 (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9a36f6204bae119a8cae0d546b441919 https://doi.org/10.1093/alcalc/agad036 Zobrazit plný text záznamu