Clinical prognostic variables in young patients (under 40 years) with hepatitis B virus-associated hepatocellular carcinoma
| Autor: | Fotini Manizate, Gerald Villanueva, Wei Luan, Qin Wang, Nuh N. Rahbari, Spiros P. Hiotis, Herman T. Yee |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Hepatitis B virus
medicine.medical_specialty Cirrhosis business.industry medicine.medical_treatment Gastroenterology Hepatitis C Hepatitis B Liver transplantation Milan criteria medicine.disease medicine.disease_cause digestive system diseases Internal medicine Hepatocellular carcinoma medicine business Viral hepatitis |
| Zdroj: | Journal of Digestive Diseases. 13:214-218 |
| ISSN: | 1751-2972 |
| DOI: | 10.1111/j.1751-2980.2012.00577.x |
| Popis: | OBJECTIVE: The aim of this study was to determine the impact of hepatocelluar carcinoma (HCC) screening in chronic hepatitis B patients who did not meet the current screening recommendations. METHODS: Patients who were admitted to Bellevue Hospital Center with HCC were assessed for risk factors, cirrhosis and tumor-specific factors. Eligibility for liver transplantation or resection with favorable outcome was determined by applying Milan criteria. RESULTS: In all 93 patients were diagnosed with hepatitis B virus (HBV)-associated HCC, 18 of whom were under 40 years. Cirrhosis was infrequently associated with HCC in this group, with most cancers occurring in non-cirrhotic patients (12/18, 66.7%). No patient developed HCC outside the American Association for the Study of Liver Diseases (AASLD) cancer screening recommendations (young age, non-cirrhotic) were eligible for liver transplantation or resection with favorable outcomes (within Milan criteria). However, HCC patients who were diagnosed within AASLD screening recommendations did meet Milan criteria in 17.3% (14/81) patients. CONCLUSIONS: Current guidelines for HCC screening in patients with HBV may lead to a delay in diagnosis in non-cirrhotic patients under 40 years. Consideration should be given to modifying current recommendations to advocate entering HBV patients into a cancer-screening program at young age. |
| Databáze: | OpenAIRE |
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