Cadinane-type sesquiterpenoids and an indolizine alkaloid from the rice fermentation of the fungus Rigidoporus microporus
| Autor: | Rong Huang, Ji-Kai Liu, He-Ping Chen, Rui Ma, Tao Feng, Yue-Ling Peng, Hui-Xiang Yang, Qian Li, Zheng-Hui Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Chemistry Alkaloid Rigidoporus microporus Plant Science Fungus biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Fermentation Indolizine No production Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology |
| Zdroj: | Phytochemistry Letters. 32:119-122 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2019.05.016 |
| Popis: | Two previously undescribed cadinane-type sesquiterpenoids, rigidoporones A and B (1 and 2), along with an undescribed racemic indolizine alkaloid, (±)-rigidoporine A (3), were isolated from the rice fermentation of the wood-decay fungus Rigidoporus microporus. The structures of the compounds were established by extensive spectroscopic methods, including 1D & 2D NMR and HRMS spectroscopic analysis. Compounds 1 and 3 were evaluated for their inhibitory activity on NO production in murine monocytic RAW264.7 macrophages (IC50 > 25 μM). |
| Databáze: | OpenAIRE |
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