The effects of three metabolic inhibitors on digestive proteinase production in Rhodnius prolixus Stål (Hemiptera: Reduviidae)

Autor:	A.E.R. Downe, Jon G. Houseman
Rok vydání:	1983
Předmět:	chemistry.chemical_classification Cordycepin Physiology Cathepsin D Cycloheximide Biology biology.organism_classification Aminopeptidase Cathepsin B chemistry.chemical_compound Enzyme chemistry Biochemistry Insect Science Extracellular Rhodnius prolixus
Zdroj:	Journal of Insect Physiology. 29:317-321
ISSN:	0022-1910
DOI:	10.1016/0022-1910(83)90032-x
Popis:	Mated female Rhodnius prolixus were fed citrated rabbit blood containing cordycepin, cycloheximide and 5-fluorouracil. The effect of these compounds on cathepsin B, cathepsin D and aminopeptidase levels in the posterior midgut was determined. Cycloheximide and 5-fluorouracil decreased the levels of all three proteinases in a dose-dependent manner. Cordycepin decreased the levels of cathepsin B and D but did not alter the aminopeptidase levels in a similar manner. These results indicate that after ingestion of a blood meal, production of the extracellular catheptic enzymes is dependent on both RNA and protein synthesis while production of the intracellular aminopeptidase depends on protein synthesis alone. The effects of these compounds on proteinase activity cycles also supports this conclusion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9a2ac714d5144cb8371e567e0bfeefa2 https://doi.org/10.1016/0022-1910(83)90032-x Zobrazit plný text záznamu