Sugar-based poly (anhydride-ester) containing natural antioxidants and antimicrobials: Synthesis and formulation into polymer blends
| Autor: | Kathryn E. Uhrich, Michelle M Moy, Nicholas D. Stebbins, Jonathan J. Faig |
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| Rok vydání: | 2016 |
| Předmět: |
Antioxidant
Polymers and Plastics medicine.medical_treatment Food spoilage Active packaging Bioengineering 04 agricultural and veterinary sciences 02 engineering and technology Bacterial growth 021001 nanoscience & nanotechnology Antimicrobial 040401 food science Biomaterials Food packaging chemistry.chemical_compound 0404 agricultural biotechnology chemistry Materials Chemistry medicine Tartaric acid Organic chemistry 0210 nano-technology Thymol |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 32:196-208 |
| ISSN: | 1530-8030 0883-9115 |
| Popis: | Thymol, a naturally occurring antioxidant and antimicrobial, is commonly researched for active packaging applications to deter food spoilage and bacterial growth. However, the high temperature necessary for processing often volatilizes the thymol, reducing its utility. To overcome this processing limitation, sugar-based poly(anhydride-esters) comprising thymol and compounds generally regarded as safe (succinic and tartaric acid) were successful prepared via mild solution polymerization methods. In vitro release studies demonstrated a sustained thymol release over 3 weeks at therapeutically relevant concentrations. Furthermore, the released thymol displayed antioxidant and antimicrobial activities as indicated by a 2,2-diphenyl-1-picrylhydrazyl radical scavenging and Kirby–Bauer disk diffusion assays, respectively. High-temperature melt blending with low-density polyethylene revealed that the chemical incorporation of thymol into a polymer backbone overcame volatility issues and maintained relevant bioactivity. |
| Databáze: | OpenAIRE |
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