Reactions of alkoxy and peroxy radicals formed upon the decomposition of hydroxyperoxide groups in the artemisinin derivatives

Autor:	Evgenii T Denisov, S. L. Solodova
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Reaction rate constant chemistry Radical Intramolecular force Polyatomic ion Alkoxy group Molecule General Chemistry Photochemistry Peroxide Medicinal chemistry Redox
Zdroj:	Russian Chemical Bulletin. 58:777-785
ISSN:	1573-9171 1066-5285
Popis:	The enthalpies of intramolecular reactions of alkoxy and peroxy radicals formed from polyatomic artemisinin hydroperoxides and of their bimolecular reactions with C—H, S—H, and O—H bonds of biological substrates were calculated. The activation energies and rate constants of these reactions were calculated using the intersecting parabolas method. The decomposition of artemisinin hydroperoxides can initiate the cascade of intramolecular oxidation reactions involving radicals R·, RO·, HO·, HO2·, and RO2·. The main sequences of transformation of these radicals were established. The oxidative destruction of the artemisinin peroxy derivatives generates radicals RO2·, HO·, and HO2· in an amount of 4.5 radicals per peroxide derivative molecule on the average. The kinetic scheme of oxidative transformations of the hydroperoxide with four OOH groups and radicals formed from it was constructed using this radical as an example.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9a0ac8c8a004bdc2d53d2115ab554846 https://doi.org/10.1007/s11172-009-0094-3 Zobrazit plný text záznamu Full text from SpringerLink