Treatment Outcomes and Prognostic Factors in Patients with Multidrug-Resistant Tuberculosis in Korean Private Hospitals

Autor:	Deog Kyeom Kim, Yang Jin Jegal, Jaemin Lim, Tae Hyung Kim, Jin Won Huh, Yu Il Kim, Hyuk Pyo Lee, Hee Jin Kim, Ki Man Lee, Ki Hwan Jung, Sook Hee Song, Jae-Joon Yim, Won-Jung Koh, Jae Yeol Kim, Jae Chol Choi, Eun Kyung Kim, I Nae Park, Tae Sun Shim, Jae Seuk Park, Jinkyeong Park, Moo Suk Park, Jin Hwa Lee, Seung Heon Lee
Rok vydání:	2010
Předmět:	Pulmonary and Respiratory Medicine medicine.medical_specialty Pediatrics Tuberculosis business.industry Public health Medical record Treatment outcome Extensively drug-resistant tuberculosis medicine.disease Multiple drug resistance Infectious Diseases medicine Advanced disease In patient business
Zdroj:	Tuberculosis and Respiratory Diseases. 69:95
ISSN:	2005-6184 1738-3536
Popis:	Background: The increasing rate of drug-resistant tuberculosis (TB) is a threat to the public health and TB control. In Korea, about 75∼80% of TB patients are treated in private hospitals and the rate has been continuously increasing since 2000. Methods: On a retrospective basis, we enrolled 170 newly diagnosed with or retreated for multidrug-resistant TB (MDR-TB) in 2004 from 21 private hospitals. We extracted the following demographics and treatment history from patient medical records: initial treatment outcomes, cumulative survival rates, treatment outcomes, and prognostic factors. Results: Of the 170 patients, the majority were male (64.1%), the mean age was 44.5 years old, and mean body- mass-index was 20.2 kg/m 2 . None of the patients tested positive for HIV. Eleven (6.5%) were confirmed to have extensively drug-resistant TB (XDR-TB) at treatment initiation. Treatment success rates were not different between XDR-TB (36.4%, 4/11) and non-XDR MDR-TB (51.6%, 82/159). Default rate was high, 21.8% (37/170). Far advanced disease on X-ray was a significant negative predictor of treatment success; advanced disease and low BMI were risk factors for all-cause mortality. Conclusion: In private hospitals in Korea, the proportion of XDR-TB in MDR-TB was comparable to previous data. The treatment success rate of MDR-/XDR-TB remains poor and the failure rate was quite high. Adequate TB control policies should be strengthened to prevent the further development and spread of MDR-/XDR-TB in Korea.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9a084689388a5b2ac2b3ce60c1337325 https://doi.org/10.4046/trd.2010.69.2.95 Zobrazit plný text záznamu