Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses
| Autor: | David Wang, John K. S. Chia, Andrew Y. Chia, Rabiha El-Habbal |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Gastrointestinal tract
medicine.medical_specialty Pathology business.industry Encephalomyelitis Stomach Chronic gastritis medicine.disease medicine.disease_cause Gastroenterology medicine.anatomical_structure Internal medicine Gastric mucosa Mild Chronic Inflammation Chronic fatigue syndrome Medicine Enterovirus business |
| Zdroj: | Open Journal of Gastroenterology. :21-27 |
| ISSN: | 2163-9469 2163-9450 |
| DOI: | 10.4236/ojgas.2015.54005 |
| Popis: | After decades of research, functional dyspepsia (FD) remains one of the most elusive gastrointestinal disorders. Endoscopic appearance of mild inflammation of the gastric mucosa without ulceration and microscopic evidence of mild chronic inflammation are often considered as normal findings since no etiology could be found other than H. Pylori. Enteroviruses infect the gastrointestinal tract and have been shown to persist in the stomach of symptomatic patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, we evaluated FD patients with and without the diagnosis of ME/CFS, and were able to support the viral protein staining with finding of double-stranded RNA in 63% of the same stomach biopsies by immunoperoxidase staining. Furthermore, we clarified the possible cross-reaction with creatine kinase brain subtype (CKB), present in parietal cells, using antibody competition experiments and western blot analysis of stomach proteins. Viral protein+ and dsRNA+ biopsies were infectious in SCID mice. More research is needed to elucidate the mechanism of enterovirus infection of the stomach associated with FD and chronic gastritis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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