Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones

Autor:	Günther Snatzke, Wolfgang Voelter, Helmut Duddeck, Shahnaz Perveen, Mashooda Hasan, Farnaz Malik, Khalid Mohammed Khan
Rok vydání:	1995
Předmět:	Circular dichroism Stereochemistry Chemistry Organic Chemistry General Chemistry Optically active Ring (chemistry) Lofendazam Medicinal chemistry chemistry.chemical_compound medicine Physical and Theoretical Chemistry Benzene medicine.drug
Zdroj:	Liebigs Annalen. 1995:1861-1869
ISSN:	1099-0690 0947-3440
DOI:	10.1002/jlac.1995199510261
Popis:	A route to optically active variously substituted 4-methyl- and 4-methyl-7-substituted 1,3,4,5-tetrahydro-2H-1,5-benzo-diazepin-2-ones as analogues of commercially available Lofendazam (7-chloro-5-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1) was developed. Fortyone variously substituted optically active compounds having the same configuration were prepared and the UV and CD spectra of the parent compounds bearing no additional substitution in the benzene ring are discussed.
Databáze:	OpenAIRE
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