Role of Pneumococcal NanC in the Severe Disease of Streptococcus pneumoniae Superinfection with Influenza
| Autor: | Yu-Lin Huang, Avijit Dutta, Yu-Chia Hsieh, Ting-An Chen, Chun-Yen Lin, Tse-Ching Chen, Yi-Yin Chen, Ching-Tai Huang, Chia-Shiang Chang, Yung-Chang Lin |
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| Rok vydání: | 2021 |
| Předmět: |
biology
business.industry viruses Immunology virus diseases Virulence General Medicine biochemical phenomena metabolism and nutrition medicine.disease_cause Virus Microbiology Immune system Immunity Superinfection Streptococcus pneumoniae biology.protein Immunology and Allergy Medicine business Neuraminidase Pathogen |
| Zdroj: | ImmunoHorizons. 5:210-218 |
| ISSN: | 2573-7732 |
| DOI: | 10.4049/immunohorizons.2100020 |
| Popis: | Bacterial superinfection aggravates the disease of influenza. Streptococcus pneumoniae is the most common bacterial pathogen. Synergistic virulence has been demonstrated between influenza neuraminidase and pneumococcal NanA and NanB. NanC, the other pneumococcal neuraminidase infrequently present in clinical isolates, is not well characterized. In this study, we report that superinfection with a NanC-negative pneumococcus strain suppresses anti-influenza immunity and impairs viral clearance with higher TGF-β activation in mice. Bacterial load in the lungs also increases as the host immunity is suppressed. NanC-positive isogenic mutant reverses wild type S. pneumoniae–mediated immune suppression and facilitates virus clearance. However, it causes more severe disease as the augmented inflammation causes collateral damage. Both virus-mediated damage and immune response–mediated inflammation are important for pathogenesis of severe influenza. Inflammation may be more critical than virus-mediated damage in influenza with bacterial superinfection. |
| Databáze: | OpenAIRE |
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