A novel GSH responsive poly(alpha-lipoic acid) nanocarrier bonding with the honokiol-DMXAA conjugate for combination therapy
| Autor: | Dawei Zhang, Jiatan Wu, Xinghui Si, Zhilin Liu, Na Shen, Zhaohui Tang, Xuesi Chen |
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| Rok vydání: | 2019 |
| Předmět: |
Honokiol
Materials science Combination therapy Alpha-Lipoic Acid 02 engineering and technology Glutathione Pharmacology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Lipoic acid chemistry Nanomedicine General Materials Science Nanocarriers 0210 nano-technology Conjugate |
| Zdroj: | Science China Materials. 63:307-315 |
| ISSN: | 2199-4501 2095-8226 |
| DOI: | 10.1007/s40843-019-1183-0 |
| Popis: | The key to improve the therapeutic efficacy for cancer treatment is to increase the delivery of drugs to tumors. For this purpose, tumor-microenvironment stimuli- responsive materials have great potential. Here, we prepared a new nanomedicine by bonding the conjugate of honokiol (HNK) and 5,6-dimethylxanthenone-4-acetic acid (DMXAA) to a glutathione (GSH)-responsive nanocarrier, poly( α -lipoic acid) polyethylene glycol. The nanomedicine would disintegrate due to the high level of GSH at the tumor sites, achieving the co-delivery of HNK and DMXAA, and realizing the combination therapy through close-range killing by HNK and long-range striking by DMXAA together. In a murine 4T1 breast tumor model, this strategy exhibited high tumor inhibition rate of 93%, and provided a valuable therapeutic choice for cancer therapy. |
| Databáze: | OpenAIRE |
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