Properties of Intimal Layer and Adjacent Flow
| Autor: | Dali J. Patel, Ramesh N. Vaishnav, H. Bulent Atabek |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Materials science
Endothelium General Engineering Pulsatile flow Blood flow chemistry.chemical_compound medicine.anatomical_structure chemistry medicine.artery medicine Shear stress General Earth and Planetary Sciences Thoracic aorta Geotechnical engineering Shear flow General Environmental Science Blood vessel Evans Blue Biomedical engineering |
| Zdroj: | Journal of the Engineering Mechanics Division. 104:67-77 |
| ISSN: | 2690-2427 0044-7951 |
| DOI: | 10.1061/jmcea3.0002328 |
| Popis: | The importance of the information on mechanical properties of the intimal layer and adjacent flow fields in studies of vessel wall permeability and pathogenesis of atherosclerosis is well recognized. The intimal layer was studied in excised segments of the blood vessel stretched to in vivo dimensions. The endothelium could withstand large normal stresses but was easily eroded by the shear stress resulting from a jet efflux. Relatively hard areas in the intimal layer distal to the intercostal orifices were found to relate to the increased collagen content and lower permeability to Evans blue dye. With the nonlinear theory of blood flow it was possible to compute accurately the pulsatile velocity profile and wall shear during a cardiac cycle in the descending thoracic aorta of a dog. The peak wall shear, under conditions of increased flow, approached the value 270 dyne/cm²; this value is close to the critical yield stress (400 dyne/cm²) for endothelial cells. |
| Databáze: | OpenAIRE |
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