Hepatitis A – kombinierte protrahierte zweigipflige und cholestatische Verlaufsform

Autor:	H Diepolder, F T Kolligs, L Schmidt, R Zachoval
Rok vydání:	2011
Předmět:	Hepatitis medicine.medical_specialty business.industry Nausea Hepatitis A Infection Hepatitis A General Medicine medicine.disease Gastroenterology Virus Serology Cholestasis Internal medicine Medicine Liver function medicine.symptom business
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 136:1057-1059
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-0031-1275842
Popis:	HISTORY AND ADMISSION FINDINGS One month after a first manifestation of a hepatitis A infection and transaminases had become normal, a 44-year-old woman again became jaundiced with accompanied by weakness, nausea and nocturnal sweating. INVESTIGATIONS Laboratory tests again showed features of hepatitis with decreased synthetic liver function and hyperbilirubinemia, changes which persisted for 12 weeks. Serological and virological studies revealed a positive test for anti-hepatitis A virus (HAV) IgM and HAV-RNA was detected in the stool. DIAGNOSIS, TREATMENT AND COURSE These tests demonstrated two rare features of hepatitis A, namely a prolonged biphasic course combined with cholestasis form. In addition a hemolytic anaemia developed. CONCLUSION The severity of a relapse of hepatitis A varies: in this case it was more severe than the initial manifestation. The reasons for the different courses of hepatitis A infection remain unclear.
Databáze:	OpenAIRE
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