P159 Faecal S100A12 as a non-invasive marker of inflammatory activity in Inflammatory Bowel Disease
| Autor: | S Cenni, M Casertano, A M Caprio, D Pacella, E Miele, M Martinelli, A Staiano, C Strisciuglio |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Crohn's and Colitis. 16:i234-i235 |
| ISSN: | 1876-4479 1873-9946 |
| Popis: | Background Calgranulin-C (f-S100A12) and zonulin are considered faecal marker of intestinal inflammation. The aim of our study was to evaluate f-S100A12 and fecal zonulin as alternative markers in the follow-up of IBD children to monitore the disease activity and to predict the clinical and endoscopic relapse, compared with FC and serum inflammatory markers. Methods Between September 2019 and March 2020, we prospectively enrolled all IBD pediatric patients, both Crohn’s Disease (CD) and Ulcerative Colitis (UC). S100A12, zonulin and faecal calprotectin (FC) were determined by enzyme-linked immunosorbent assay (ELISA). Results One hundred seventeen consecutive children, 39.3% with CD and 71 60.7% with UC were enrolled. No differences were found for FC, f-S100A12 and zonulin values in UC and CD. In both CD and UC there was a direct correlation between FC and f- S100A12 levels (r=0.54; p Conclusion Our data suggest that f-S100A12 and FC but not F-zonulin are useful non-invasive biomarkers in the management of pediatric IBD in follow up and to monitor endoscopic relapse in CD patients. |
| Databáze: | OpenAIRE |
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