Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs
| Autor: | David S. Bayless, Grace M. Meers, Nicholas J. Fleming, Jaume Padilla, Rebecca J. Welly, Sewon Lee, Victoria J. Vieira-Potter, Michael A. Hill, R. Scott Rector, Thomas N. Smith, Rebecca J. Scroggins |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) Adipose tissue Inflammation 030204 cardiovascular system & hematology Proinflammatory cytokine Coronary artery disease 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Internal medicine medicine 030304 developmental biology 2. Zero hunger 0303 health sciences Nutrition and Dietetics business.industry Insulin medicine.disease medicine.symptom Panniculitis business Dyslipidemia |
| Zdroj: | Obesity. 23:2421-2429 |
| ISSN: | 1930-7381 |
| DOI: | 10.1002/oby.21252 |
| Popis: | Objective The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here. Methods Young female Ossabaw pigs were fed a Western-style high-fat diet (HFD) (n = 4) or control low-fat diet (LFD) (n = 4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation. Results The HFD-fed “OBESE” pigs were 2.5 times heavier (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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