Molecular Epidemiology of ALK Rearrangements in Advanced Lung Adenocarcinoma in Latin America
| Autor: | Julia Angelina Sáenz-Frías, Carlos Vargas, Erica Rojas-Bilbao, Graciela Cruz-Rico, Osvaldo Arén Frontera, Laura Beatriz Wills, Luis Corrales, Andrés F. Cardona, Cristina Fernández, George Oblitas, Laura Alejandra Ramírez-Tirado, Leonardo Rojas, Hernán Lupera, Guillermo F. Bramuglia, Gabriel Casas, Gonzalo Recondo, Sergio Sánchez-Sosa, Ernesto Jiménez-García, Alejandro Avilés-Salas, Hernán Carranza, Mauricio Cuello, Luis-Alberto Mas-Lopez, Horacio Astudillo, Victoria Imaz-Olguín, Ernestina Pichelbaur, Claudio Martin, Omar Castillo, Oscar Arrieta, Luis E. Raez, Antonio Piottante, Valeria Denninghoff |
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| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
medicine.medical_specialty Latin Americans Lung Molecular epidemiology medicine.diagnostic_test business.industry Incidence (epidemiology) General Medicine medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Internal medicine parasitic diseases medicine Population study Adenocarcinoma 030212 general & internal medicine Lung cancer business Fluorescence in situ hybridization |
| Zdroj: | Oncology. 96:207-216 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Objective: Latin American countries are heterogeneous in terms of lung cancer incidence and exposure to potential carcinogens. We evaluated the frequency and clinical characteristics of ALK rearrangements (ALKr) in Latin America. Methods: A total of 5,130 lung cancer patients from 10 Latin American countries were screened for inclusion. ALKr detection was performed by fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), and real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to assess method variability. Demographic and clinicopathologic characteristics were analyzed. Results: Among the 5,130 patients screened, 8.4% (n = 433) had nonevaluable FISH tests. Evaluable FISH analyses revealed positive ALKr in 6.8% (320/4,697) of the study population, which included patients from 9 countries. ALKr distribution for each country was: Mexico 7.6% (79/1,034), Colombia 4.1% (10/242), Argentina 6.0% (153/2,534), Costa Rica 9.5% (13/137), Panama 4.4% (5/114), Uruguay 5.4% (2/37), Chile 8.6% (16/185), Venezuela 8.9% (13/146), and Peru 10.8% (29/268). RT-PCR showed high positive (83.6%) and negative (99.7%) predictive values when compared to the gold standard FISH. In contrast, IHC only showed a high negative predictive value (94.6%). Conclusions: Although there is a clear country and continental variability in terms of ALKr frequency, this difference is not significant and the overall incidence of ALKr in Latin America does not differ from the rest of the world. |
| Databáze: | OpenAIRE |
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