| Autor: |
Jernej Pusnik, Werner O. Monzon-Posadas, Jasmin Zorn, Kathrin Peters, Maximilian Baum, Hannah Proksch, Celina Beta Schlüter, Galit Alter, Tanja Menting, Hendrik Streeck |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-2053251/v1 |
| Popis: |
The elicited anti-SARS-CoV-2 immunity worldwide is becoming increasingly complex with individuals receiving a different amount of vaccine doses paired with or without recovery from breakthrough infections with different variants. To understand the variety of anti-SARS-CoV-2 immunity we analyzed the adaptive immune responses of individuals that initially received 2 doses of mRNA vaccine and either received a booster vaccination, recovered from a breakthrough infection, or both. Our data suggest that two vaccine doses and delta breakthrough infection or three vaccine doses and optionally omicron or delta infection provide better B cell immunity than the initial 2 doses of mRNA vaccine with or without alpha breakthrough infection. A particularly potent humoral response against the currently circulating omicron variant was observed for the thrice vaccinated individuals with omicron breakthrough infection; a 46-fold increase in neutralization compared to 2 vaccine doses (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
