Acid suppression in healthy subjects following lansoprazole or pantoprazole

Autor:	Y. L. n Chiu, J.-Q. Huang, Cindy James, B. L. Pilmer, Abr Thomson, S. A. Appelman, Subbaramiah Sridhar, R. G. Keith, D. R. Goldwater, Richard H. Hunt
Rok vydání:	2002
Předmět:	medicine.medical_specialty Randomization Hepatology business.industry Stomach Gastroenterology Lansoprazole Pharmacology Crossover study medicine.anatomical_structure Pharmacokinetics Internal medicine Ambulatory medicine Gastric acid Pharmacology (medical) business medicine.drug Pantoprazole
Zdroj:	Alimentary Pharmacology & Therapeutics. 16:425-433
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2002.01168.x
Popis:	Aim: To compare the effect of lansoprazole, 30 mg once daily, with that of pantoprazole, 40 mg once daily, for the inhibition of gastric acid secretion. Methods: Two randomized, single-blind, two-way, crossover studies were conducted in 74 healthy male volunteers. Lansoprazole, 30 mg, or pantoprazole, 40 mg, was administered once daily for five consecutive days with at least a 2-week washout period between regimens. Ambulatory 24-h intragastric pH was recorded at baseline and on days 1 and 5 of each crossover treatment period. Results: On day 1 in both studies, lansoprazole, 30 mg, produced significantly higher mean 24-h intragastric pH values when compared to pantoprazole, 40 mg (3.78 vs. 3.08, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::99a3e5a4a0fbe921caf874dd9d746ab1 https://doi.org/10.1046/j.1365-2036.2002.01168.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.