Effects of cholecystokinin-octapeptide and cerulein on small-intestinal motility in sheep
| Autor: | K. W. Romański |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Contraction (grammar) 040301 veterinary sciences Chemistry digestive oral and skin physiology 0402 animal and dairy science 04 agricultural and veterinary sciences digestive system 040201 dairy & animal science Small intestine 0403 veterinary science Endocrinology medicine.anatomical_structure Internal medicine Duodenal bulb medicine Duodenum Animal Science and Zoology Migrating motor complex Ceruletide Cholecystokinin Hormone |
| Zdroj: | Czech Journal of Animal Science. 55:321-329 |
| ISSN: | 1805-9309 1212-1819 |
| DOI: | 10.17221/1692-cjas |
| Popis: | Cholecystokinin (CCK) affects the intestinal motility but in ruminants the question has not been entirely explored. The aim of this study was to examine the precise effects of CCK-octapeptide (CCK-OP) and its amphibian analogue, cerulein, on duodenal motor activity in unfasted rams in the course of chronic experiments. Five rams underwent the implantation of a strain gauge force transducer to the duodenal wall, and – additionally – the bipolar platinum electrodes to the duodenal bulb, distal duodenum, near the strain gauge force transducer, and proximal jejunum. During continuous motor recordings, 0.15M NaCl or CCK peptides were administrated intravenously. Injections of CCK-OP at doses of 20 (over 30 s), 200 (over 30 or 60 s), and 2 000 (over 30, 60, or 120 s) ng/kg of body weight and injections of cerulein at doses of 1, 10, or 100 ng/kg (given over the same periods) were each administered in the course of duodenal phase 1, 2a, or 2b of the migrating motor complex (MMC), i.e. 5 min after the onset of each phase. Injections of the smallest doses of CCK peptides exerted a slight and mostly insignificant effect on the duodenal areas under contraction (AUC). In the duodenum, the moderate doses of the hormones evoked short stimulatory effects followed by longer inhibitory biphasic effects on AUC. These effects were inversely related to the duration of the hormone injection. It is concluded that CCK evokes stimulatory and inhibitory (biphasic) physiological effects on duodenal motility in sheep. |
| Databáze: | OpenAIRE |
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