Paradoxical influence of combined effect of Semax and ammonium molybdate on learning and memory in rats
| Autor: | S.B. Bokieva, O.V. Karpukhina, A. N. Inozemtsev, A. A. Kamenskii, K. Z. Gumargalieva, N. F. Myasoedov |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Ammonium molybdate Antioxidant 030102 biochemistry & molecular biology Chemistry medicine.medical_treatment Semax Biological activity Heavy metals medicine.disease_cause General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology Biochemistry Avoidance reaction medicine Neurotoxic effect General Agricultural and Biological Sciences Oxidative stress General Environmental Science medicine.drug Nuclear chemistry |
| Zdroj: | Moscow University Biological Sciences Bulletin. 72:151-154 |
| ISSN: | 1934-791X 0096-3925 |
| DOI: | 10.3103/s0096392517030051 |
| Popis: | The combined effect of Semax with water solutions of plumbum diacetate (10–7 M) and ammonium molybdate (10–5 M) on the two-way active avoidance learning in rats in the shuttle chamber was studied. It was established that both salts of heavy metals oppress the learning and memory; plumbum diacetate caused larger oppression. Semax slowed down the development of the conditioned response but counteracted the negative influence on this process from the side of both metals. The effect of Semax on the development of the avoidance reaction in the presence of ammonium molybdate, which oppressed the avoidance by itself, paradoxically intensified. During the combined effect of the peptide and ammonium molybdate, the development of the conditioned reaction occurred much faster than against the background of Semax without the combination with molybdenum. In total, data obtained indicate a counteraction of Semax to neurotoxic effect of plumbum and molybdenum salts. Since oxidative stress is the main mechanism of neurotoxic effect of heavy metals, the indicated positive effect of Semax can, in our opinion, confirm the presence of antioxidant properties in the spectrum of the peptide pharmacological activity. |
| Databáze: | OpenAIRE |
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