| Autor: |
Heather Fecteau, Tuya Pal |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Next Generation Sequencing in Cancer Research, Volume 2 ISBN: 9783319158105 |
| DOI: |
10.1007/978-3-319-15811-2_6 |
| Popis: |
Over the last decade, there have been tremendous advances in genetic testing through the development of next-generation sequencing (NGS) technologies. This has led to plummeting costs of testing making it possible to test for multiple genes simultaneously at a cost comparable to testing for 1–2 genes through older Sanger sequencing technology. As a consequence, clinical practice has been greatly impacted resulting in the need to develop new models for genetic counseling and informed consent. This chapter will highlight clinical considerations when using NGS to evaluate for inherited cancer predisposition. Topics to be covered include factors to consider when conducting NGS tests, considerations of various multigene tests available, resulting paradigm shifts, and other clinical and laboratory considerations when testing is conducted. We will conclude with the evolving role of genetics health professionals given the emerging landscape and highlight the importance of education and outreach efforts. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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