Chemiluminescence response of whole blood and separated blood cells in cases of experimentally induced pancreatitis and MDTQ-DA—Trasylol—ascorbic acid therapy

Autor:	R. Schuster, T. Zimmermann, S. Kopprasch, M. Trausch, H. Kuehne, G. Lauschke, S. Albrecht
Rok vydání:	1991
Předmět:	Glutathione Pharmacology medicine.disease Ascorbic acid Biochemistry Analytical Chemistry law.invention Luminol chemistry.chemical_compound chemistry law In vivo medicine Environmental Chemistry Pancreatitis Acute pancreatitis Spectroscopy Whole blood Chemiluminescence
Zdroj:	Analytica Chimica Acta. 255:373-381
ISSN:	0003-2670
DOI:	10.1016/0003-2670(91)80071-z
Popis:	The formation of reactive O 2 species in the pancreas of pigs after induction of necrotizing or oedematous pancreatitis was studied by means of luminol- and lucigenim-sensitized chemiluminescence. The effect of 2,2-dimethyl-4-methanesulphonic acid-1,2-dihydroquinoline in combination with Trasylol and ascorbic acid was studied in vivo. This combined therapy leads to a reaction in the chemiluminescence response by 50–70% with prevention of pancreatogenic shock and multiple organ failure by improvement of the glutathione status. The combination of radical traps, kallikrein inhibitors and natural antioxidative substances is an efficient alternative therapy in cases of acute pancreatitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::997f4d661bdbaadc74fa3e7b6468b547 https://doi.org/10.1016/0003-2670(91)80071-z Zobrazit plný text záznamu