Does the Anti-Oxidant Lycopene Inhibit the Killing of Prostate Cancer Cells by Radiation?
| Autor: | Aaron E. Katz, Richard M. Gewanter, Ronald D. Ennis, Peter B. Schiff, Charles R. Geard, Adayabalam S. Balajee |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
chemistry.chemical_classification
Oncology Cancer Research medicine.medical_specialty Antioxidant medicine.medical_treatment Linear energy transfer medicine.disease In vitro Lycopene Radiation therapy chemistry.chemical_compound Prostate cancer medicine.anatomical_structure chemistry Prostate Internal medicine medicine Cancer research Carotenoid |
| Zdroj: | The Cancer Journal. 8:503 |
| ISSN: | 1528-9117 |
| DOI: | 10.1097/00130404-200211000-00072 |
| Popis: | Purpose: Lycopene is a potent antioxidant that has been shown to be the most efficient quencher of singlet oxygen radicals among the biological carotenoids. Men with elevated plasma lycopene levels have a lower risk of developing prostate cancer. Some physicians recommend lycopene-containing regimens for prostate caner patients, including those receiving radiation therapy for their disease. Because the killing of tumor cells by low linear energy transfer (LET) radiation is largely mediated by free-radical damage to cellular DNA, the concomitant use of lycopene and radiotherapy could diminish effectiveness of the radiation. We assessed the likelihood of lycopene reducing radiation effectiveness by performing a clonogenic survival assay on prostate cancer cells in vitro. Material and Methods: DU-145 prostate cancer cells were irradiated with 137Cs gamma rays (1.1 Gy/min) in the presence or absence of lycopene at reported maximal plasma concentration (1 micromolar) or twice-maximal plasma concentration (2 micromolar). Experiments were performed under dim lighting. Cells were incubated for 17 days, fixed and stained, and colonies counted in standard fashion. Results: There was no evidence of a radioprotective effect of lycopene. In fact, lycopene appeared to enhance the ability of radiation to kill tumor cells by a factor of about 10%. Conclusions: Lycopene at plasma- or twice plasma-concentration does not inhibit the killing of DU-145 prostate cancer cells by low LET radiation in vitro. This supports the view that lycopene supplementation during radiotherapy for prostate cancer does not diminish the effectiveness of the radiation. |
| Databáze: | OpenAIRE |
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