Review : Glial Boundaries and Scars: Programs for Normal Development and Wound Healing in the Brain
| Autor: | Dennis A. Steindler, L. Brannon Thomas |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology Traumatic brain injury General Neuroscience Regeneration (biology) Neurodegeneration Scars Biology medicine.disease Neuroregeneration Neuroscientist Extracellular matrix 03 medical and health sciences 030104 developmental biology medicine Neurology (clinical) medicine.symptom Wound healing Neuroscience |
| Zdroj: | The Neuroscientist. 1:142-154 |
| ISSN: | 1089-4098 1073-8584 |
| Popis: | Early studies of glial boundaries, which are composed of immature astrocytes and extracellular matrix mol ecules (which they express), initially offered insight into the partitioning that occurs in the developing nervous system. More recently, however, it has been suggested that similar "boundaries" may have important roles in other processes occurring in the brain, including repair after traumatic brain injury. As more is understood about the expression and function of boundary molecules and glia, their potential importance is becoming apparent in numerous neuropathological conditions, including neurodegeneration and neuroregeneration in Alzheimer's and Huntington's diseases as well as in brain neoplasms. Furthermore, before we can hope to fully understand and facilitate regeneration in the compromised brain, our knowledge of the glial boundary, both during development and in the adult, must be more complete. The Neuroscientist 1:142-154, 1995 |
| Databáze: | OpenAIRE |
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