Phytotoxic lignans ofLeucophyllum frutescens

Autor: Agnes M. Rimando, Rita M. Moraes, Franck E. Dayan, Julie Rakel Mikell
Rok vydání: 1999
Předmět:
Zdroj: Natural Toxins. 7:39-43
ISSN: 1522-7189
1056-9014
DOI: 10.1002/(sici)1522-7189(199902)7:1<39::aid-nt38>3.0.co;2-2
Popis: Bioassay-guided fractionation of the hexane:ethyl acetate (1:1) extract of the leaves of Leucophyllum frutescens (Berl.) I.M.Johnst (Scrophulariaceae) led to the isolation of its phytotoxic constituents diayangambin (1), epiyangambin (2), diasesartemin (3) and epiashantin (4). Phytotoxicity was demonstrated as inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lactuca sativa L. (Asteraceae) seedlings in a microassay using 24-well plates. Compound 1 was the most phytotoxic to L. sativa, showing strong inhibitory activity at 110 µM. Compound 1 was more active than 2 and 3 in inhibiting the growth of A. stolonifera with I50 values of 160, 670 and 930 µM, respectively. At a concentration of 500 µM, these compounds inhibited all phases of onion root cell division. This is the first demonstration of antimitotic activity of these furofuran lignans, and the first report of their isolation from this species. Copyright © 1999 John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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