Soluble Tumor Necrosis Factor Alpha Receptor 1, Bone Resorption, and Bone Mineral Density in the Year Following Hip Fractures: The Baltimore Hip Studies
| Autor: | Michelle Shardell, Neal S. Fedarko, Ram R. Miller, Marc C. Hochberg, Ann L. Gruber-Baldini, Shabnam Salimi, Jack M. Guralnik, Denise Orwig, Jay Magaziner |
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| Rok vydání: | 2018 |
| Předmět: |
Bone mineral
medicine.medical_specialty Hip fracture business.industry Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Systemic inflammation medicine.disease Bone resorption Bone remodeling Resorption 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Orthopedics and Sports Medicine 030212 general & internal medicine medicine.symptom TUMOR NECROSIS FACTOR-ALPHA RECEPTOR business Type I collagen |
| Zdroj: | Journal of Bone and Mineral Research. 33:1649-1656 |
| ISSN: | 0884-0431 |
| Popis: | Although inflammation is known to influence bone turnover and bone mineral density (BMD), less is known about role of soluble tumor necrosis factor alpha receptor 1 (sTNFα-R1) in changes in bone turnover and BMD in the year after hip fracture. We studied 245 persons (117 men and 128 women) from the Baltimore Hip Studies. Bone turnover markers of resorption (carboxy-terminal type I collagen cross-links [CTX-I]) and formation (amino-terminal propeptide type I collagen [P1NP]), BMD of the contralateral hip, and sTNFα-R1 were measured within 15 days of hospitalization and 2, 6, and 12 months later. Latent class growth modeling was used to determine sTNFα-R1 trajectories. Weighted generalized estimating equations were used to examine the association of sTNFα-R1 trajectories with serum levels of CTX-I and P1NP and BMD; standardized beta coefficients (βˆ) are reported. Higher baseline sTNFα-R1 was significantly associated with a greater rate of CTX-I change (βˆ = 0.26, p = 0.004). Four distinct sTNFα-R1 trajectories were identified. The two groups with higher sTNFα-R1 levels during the year following fracture had faster increasing levels of CTX-I compared to the group with lowest sTNFα-R1 levels (men: group 3: βˆ = 0.76, p = 0.02; group 4: βˆ = 1.4, p |
| Databáze: | OpenAIRE |
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