Two Antifungal Active Triterpene Glycosides from Sea Cucumber Holothuria (Microthele) axiloga
| Autor: | Yang-Hua Yi, Mei Xue, Wei-Hua Yuan, Hongwei Zhang, Ming-Ping La |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Antifungal
chemistry.chemical_classification Chromatography biology Chemistry medicine.drug_class Silica gel Holothurin B Glycoside General Medicine biology.organism_classification Sea cucumber chemistry.chemical_compound Complementary and alternative medicine Triterpene Drug Discovery medicine Holothuria Spectral data |
| Zdroj: | Chinese Journal of Natural Medicines. 6:105-108 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(09)60010-8 |
| Popis: | AIM To study the new antifungal active triterpene glycosides of sea cucumber Holothuria (Microthele) axiloga . METHODS Triterpene glycosides from Holothuria (Microthele) axiloga were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of chemical evidence, spectral data and chemical reactions. RESULTS Two triterpene glycosides were identified as axilogoside A ( 1 ) and holothurin B ( 2 ). CONCLUSION Axilogoside A ( 1 ) is a new triterpene glycoside, and 2 was isolated from Holothuria (Microthele) axiloga for the first time. They showed considerable antifungal activities (4⩽MIC 80 ⩽16 μg·mL −1 ) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect