| Autor: | Kotieva , Inga M., Pogorelova , Julija A., Nemashkalova , Ljudmila A., Kit , Oleg I., Cheryarina , Natal'ya D., Surikova , Ekaterina I., Kaplieva , Irina V., Trepitaki , Lidia K., Frantsiyants , Elena M., Bandovkina , Valeriya A., Neskubina , Irina V. |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| DOI: | 10.23683/0321-3005-2019-1-106-111 |
| Popis: | Aim. Studying the influence of chronic neuropathic pain on the development of В16/F10 melanoma in male mice. Methods. The study included 52 С57ВL/6 male mice. In the main group, a model of chronic neuropathic pain was created by the sciatic nerve ligation on both sides 2 weeks before the subcutaneous transplantation of melanoma; in the comparison group, melanoma was transplanted without prior chronic neuropathic pain development. Tumors were measured once a week. The animals were necropsied after their natural death, and the number of metastases was counted. Results. The development of melanoma with chronic neuropathic pain in male mice had similar characteristics re-gardless of the gender: early-onset tumors, poorer survival, similar tumor sizes at weeks 2 and 3 of the carcinogenesis, smaller volumes of tumors at the time of animal death, metastases and external necroses; specific gender differences were: smaller tumors at week 1 of carcinogenesis compared to females, single focus tumors, development of amelanot-ic melanomas, later development of external necroses, without atypical metastatic sites common to females more fre-quent and later (from week 2) development of metastases to the lungs only. Conclusions. For the translational significance of preclinical studies, it is expedient to study mechanisms of the influence of chronic neuropathic pain on the course of malignant processes in animals of both genders. |
| Databáze: | OpenAIRE |
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