A TWO YEAR HOSPITAL BASED PROSPECTIVE STUDY OF SICKLE CELL DISORDERS IN CHILDREN AND COMPARISON WITH OTHER HOSPITAL BASED REGIONAL STUDIES IN INDIA

Autor:	Vijaya Bhaskar P, Krishna L, Sunil Kumar Komanapalli, Siva Ranjan D
Rok vydání:	2014
Předmět:	education.field_of_study Pediatrics medicine.medical_specialty business.industry Population Disease Urine Jaundice medicine.disease Iron-deficiency anemia Fetal hemoglobin medicine Hemoglobin medicine.symptom Prospective cohort study education business
Zdroj:	Journal of Evolution of Medical and Dental Sciences. :649-656
ISSN:	2278-4802 2278-4748
DOI:	10.14260/jemds/2014/1880
Popis:	Various haemoglobinopathies are major health problem in east godavari district, andhra pradesh. Because of high prevalence of these disorders, we undertook limited hospital based study. AIMS: To study and to evaluate the sickle cell disorders in children who attended outpatient pediatric department, GGH, Kakinada METHODS AND MATERIAL: The present prospective study included 82 patients, referred for screening of hemoglobin disorders from October 2010 to September 2012, with Clinical history of anaemia, jaundice, splenomegaly and fever. Blood samples were collected into EDTA for testing parameters like hemogram, peripheral smear, reticulocyte count, Hb F(fetal hemoglobin) study, osmotic fragility test, Hb H Inclusion Bodies, hemoglobin analysis by HPLC (high performance liquid chromatography) and urine was collected for urobilinogen test. RESULTS: Total numbers of sickle cell disease and trait were 31 out of 82 screened cases with male predominance and six cases were sickle heterozygous conditions. The prevalence of sickle cell disorders is 37%. 54% of sickle cell cases were associated with iron deficiency anemia. Serum bilirubin levels are increased more in sickle cell disease compared to other abnormal Hb disorders. CONCLUSIONS: Our study indicates that sickle cell disease and trait were most common haemoglobinopathies. 93% of sickle cell cases had presented with Microcytic hypochromic anemia. The prevalence of sickle cell disease is 37%, although the present study is Hospital based which cannot represent any community or population, but it emphasizes the need of knowing the magnitude of this problem in this region.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9961a93d23091052eb7205dc03826bf8 https://doi.org/10.14260/jemds/2014/1880 Zobrazit plný text záznamu