Comparative efficacy of topical Adipocyte-derived Mesenchymal Stem Cells-Conditioned Medium (ADMSC-CM) and Amniotic Membrane Mesenchymal Stem Cells-Conditioned Medium (AMSC-CM) on chronic plantar ulcers in leprosy: a randomized controlled trial
Autor: | Medhi Denisa Alinda, Paulus Mario Christopher, Muhammad Yulianto Listiawan, Anang Endaryanto, Heri Suroto, Fedik Abdul Rantam, Esti Hendradi, Hari Basuki Notobroto, Sri Linuwih Susetyo Wardhani Menaldi, Cita Rosita Sigit Prakoeswa |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Bali Medical Journal. 10:958-963 |
ISSN: | 2302-2914 2089-1180 |
Popis: | Introduction: Chronic Plantar Ulcer of Leprosy (CPUL), one of the debilitating disabilities and complications, poses a treatment challenge. Utilization of stem cells, specifically adipocyte-derived mesenchymal stem cells-conditioned medium (ADMSC-CM) and amniotic membrane mesenchymal stem cells-conditioned medium (AMSC-CM), may serve as a novel therapeutic option. This study aims to compare the efficacy of topical ADMSC-CM, topical AMSC-CM, and farmazertin gauze dressing (FGD) only on the healing of CPUL.Methods: In this randomized controlled trial, our study recruited 54 subjects with CPUL. Subjects were randomly assigned to topical ADMSC-CM (n = 16), topical AMSC-CM (n = 22), or FGD (n = 16) applied every three days for up to 8 weeks. Data were analyzed using SPSS version 20 for Windows.Results: Healing percentage increased each week in all groups. Statistic differences between groups (p |
Databáze: | OpenAIRE |
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