Comparative efficacy of topical Adipocyte-derived Mesenchymal Stem Cells-Conditioned Medium (ADMSC-CM) and Amniotic Membrane Mesenchymal Stem Cells-Conditioned Medium (AMSC-CM) on chronic plantar ulcers in leprosy: a randomized controlled trial

Autor: Medhi Denisa Alinda, Paulus Mario Christopher, Muhammad Yulianto Listiawan, Anang Endaryanto, Heri Suroto, Fedik Abdul Rantam, Esti Hendradi, Hari Basuki Notobroto, Sri Linuwih Susetyo Wardhani Menaldi, Cita Rosita Sigit Prakoeswa
Rok vydání: 2021
Předmět:
Zdroj: Bali Medical Journal. 10:958-963
ISSN: 2302-2914
2089-1180
Popis: Introduction: Chronic Plantar Ulcer of Leprosy (CPUL), one of the debilitating disabilities and complications, poses a treatment challenge. Utilization of stem cells, specifically adipocyte-derived mesenchymal stem cells-conditioned medium (ADMSC-CM) and amniotic membrane mesenchymal stem cells-conditioned medium (AMSC-CM), may serve as a novel therapeutic option. This study aims to compare the efficacy of topical ADMSC-CM, topical AMSC-CM, and farmazertin gauze dressing (FGD) only on the healing of CPUL.Methods: In this randomized controlled trial, our study recruited 54 subjects with CPUL. Subjects were randomly assigned to topical ADMSC-CM (n = 16), topical AMSC-CM (n = 22), or FGD (n = 16) applied every three days for up to 8 weeks. Data were analyzed using SPSS version 20 for Windows.Results: Healing percentage increased each week in all groups. Statistic differences between groups (p
Databáze: OpenAIRE
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