Correspondence
| Autor: | Donnadieu I, Velásquez-Jones L, Kane J, Puente M, Mota-Hernández F |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Osmole
Glycylglycine chemistry.chemical_classification medicine.medical_specialty business.industry Potassium Sodium chemistry.chemical_element medicine.disease Amino acid Diarrhea chemistry.chemical_compound Infectious Diseases Endocrinology chemistry Biochemistry Internal medicine Pediatrics Perinatology and Child Health Glycine medicine Dehydration medicine.symptom business |
| Zdroj: | Journal of Tropical Pediatrics. 35:47-47 |
| ISSN: | 1465-3664 0142-6338 |
| Popis: | The efficacy of oral rehydration solutions containing glycine and glycyl-glycine in addition to the WHO formula adjusted to maintain osmolality was compared in 32 male infants under 12 months of age with diarrheal dehydration. Addition of certain amino acids and dipeptides has been reported to enhance the absorption of sodium in dehydrated children. The solution give to 16 test subjects contained 60 mmol glycine/1 and 30 mmol/1 glycyl-glycine in a WHO ORS solution with glucose reduced from 111 mmol/1 to 89 mmol/1 keeping the total osmolality at 379 mOsm/kg. The WHO solution given to 16 controls contained 90 mmol/1 sodium 80 chloride 20 potassium 10 citrate and 111 glucose with a total osmolality of 311 mOsm/kg. The test group had more episodes of diarrhea 10.3 compared to 8.0 in controls during the 1st 6 hours of rehydration. 2 controls and 3 test babies required intravenous rehydration. The results did not indicate any improvement gained by addition of glycine and its dipeptide. |
| Databáze: | OpenAIRE |
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