A Catellani and retro-Diels–Alder strategy to access 1-amino phenanthrenes via ortho- and interannular C–H activation of 2-iodobiphenyls

Autor:	Yun Liang, Xinyang Chen, Zichao Feng, Yuan Yang, Guobo Deng, Mingjie Sun
Rok vydání:	2021
Předmět:	chemistry.chemical_compound Cascade reaction Stereochemistry Chemistry Norbornadiene Organic Chemistry Functional group Diels alder Phenanthrenes
Zdroj:	Organic Chemistry Frontiers. 8:6535-6540
ISSN:	2052-4129
DOI:	10.1039/d1qo01103k
Popis:	An efficient palladium-catalyzed three-component domino reaction of 2-iodobiphenyls, O-benzoylhydroxylamines, and norbornadiene has been developed to construct diverse 1-amino phenanthrene derivatives. The methodology realizes simultaneous construction of one C–N bond and two C–C bonds via a Catellani and retro-Diels–Alder strategy by ortho- and interannular C–H activation of 2-iodobiphenyls. Furthermore, this methodology features good functional group tolerance and broad substrate scope.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::994718847f47aa50dea1cff8681bb821 https://doi.org/10.1039/d1qo01103k Zobrazit plný text záznamu