Interaction of Smad4 and Embryonic Liver Fodrin-β-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression
| Autor: | Sang Soo Kim, Charles Shuman, Lopa Mishra |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Scaffold protein
medicine.medical_specialty animal structures integumentary system Chemistry Cell respiratory system Hyperplasia medicine.disease medicine.disease_cause digestive system diseases Cell biology medicine.anatomical_structure Endocrinology Internal medicine embryonic structures Knockout mouse medicine Spectrin Signal transduction Carcinogenesis Transforming growth factor |
| Zdroj: | Transforming Growth Factor-β in Cancer Therapy, Volume I ISBN: 9781588297143 |
| DOI: | 10.1007/978-1-59745-292-2_6 |
| Popis: | Transforming growth factor (TGF)-β is both a suppressor and promoter of tumorigenesis; however, its contribution to early tumor suppression and staging remains largely unknown. In search of the mechanism of early tumor suppression, we focus on Smad4, a transducer of TGF-β signaling, and embryonic liver fodrin (ELF), a β-spectrin, in tumorigenesis by linking a major, dynamic scaffolding protein and a key signaling protein. ELF activates and modulates Smad4 activation of the TGF-β response to confer cell polarity, to maintain cell architecture, and to inhibit epithelial-to-mesenchymal transition. In human gastric tumor samples, a significant loss of ELF and reduction of Smad4 expression was recently found. An examination of elf +/− , Smad4 +/− , and elf +/− /Smad4 +/− mice revealed that disruption of ELF and Smad4 displayed a synergistic effect on tumor formation in terms of incidence and duration, suggesting a cooperative interaction between ELF and Smad4 leading to enhanced tumor suppression. This review examines our understanding of the significance of the interactions between ELF and Smad4, through regulation of the TGF-β signaling pathway and repression of tumor formation. |
| Databáze: | OpenAIRE |
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