P36 Respiratory functional status after intrapleural t-PA administration for complicated parapneumonic effusions
| Autor: | D Spyratos, K Zarogoulidis, M Sionidou, L. Sichletidis, P. Zarogoulidis, T Kontakiotis |
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| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry medicine.medical_specialty medicine.diagnostic_test business.industry medicine.drug_class Pleural effusion medicine.medical_treatment Streptokinase Antibiotics Exercise capacity medicine.disease Surgery Chest tube Medicine Functional status Respiratory system business medicine.drug |
| Zdroj: | Thorax. 66:A82-A82 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thoraxjnl-2011-201054c.36 |
| Popis: | Introduction and Objectives In a large-scale, multicentered randomised trial, intrapleural administration of streptokinase has been proved unsuccessful among patients with pleural infection but >80% of them had visibly purulent pleural fluid while small bore chest tubes (median diameter: 12F) had been used. The aim of our study was to investigate lung function and exercise capacity after intrapleural administration of recombinant tissue plasminogen activator (t-PA) in adult patients with complicated parapneumonic pleural effusion (CPE). Methods Fifteen consecutive patients (mean age 50.2±19.3 years) with CPE were included. Chest tube (13 patients: 32F, 2 patients: 10F) was inserted under guidance of computed tomography and all patients received IV antibiotics. After pleural fluid drainage has been stopped for 24 h, 25 mg t-PA/day was administered via chest tube for two consecutive days. We evaluated patients with spirometry before t-PA, 1 day after chest tube removal and 1 month after discharge. During the second and third time-point evaluations, 6 min walking test was also performed. Results Patients reported symptoms 10.7±7.4 days before hospital admission while all of them demonstrated loculated effusions on computed tomography. The mean production of fluid was 721.3±821.7 ml before and 1.500±107.1 ml after t-PA administration (p Conclusion Intrapleural administration of t-PA for CPE was an effective treatment considering functional status of the respiratory system during follow-up. |
| Databáze: | OpenAIRE |
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