T-bet+ Cells Polarization in Patients Infected with Helicobacter pylori Increase the Risk of Peptic Ulcer Development
| Autor: | Alireza Razavi, Farid Zandi, Mohammad-Javad Sanaei, Mahboobeh Nahid-Samiei, Kamran Tahmasbi, Mohammadhadi Shafigh, Hedayatollah Shirzad, Nader Bagheri, Yousef Mirzaei, Ghorbanali Rahimian |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty chemical and pharmacologic phenomena Inflammation Disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Gastric Infection biology business.industry Stomach hemic and immune systems General Medicine Helicobacter pylori biology.organism_classification medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Peptic ulcer Immunohistochemistry Gastritis medicine.symptom business |
| Zdroj: | Archives of Medical Research. 50:113-121 |
| ISSN: | 0188-4409 |
| DOI: | 10.1016/j.arcmed.2019.07.005 |
| Popis: | Background Peptic ulcer disease (PUD) is a common disease worldwide moreover known as stomach ulcer or peptic ulcer. Increased the number of T CD4+ helper cells in response to gastric infection by Helicobacter pylori (H. pylori) play an important role in the development of PUD. The aim of this study was to determine the frequency of T-bet+ cells in H. pylori-infection, its interaction with Th17/Treg cells and its association with the clinical consequences of the infection. Methods A total of 63 patients with PUD, 89 patients with gastritis and 48 H. pylori-negative subjects were enrolled in this study. The number of T-bet+ cells were determined by immunohistochemistry. Results The numbers of T-bet+ cells and INF-γ expression in infected patients were significantly higher than uninfected. Moreover, the number of T-bet+ cells and INF-γ expression in infected patients with PUD were significantly higher than infected patients with gastritis. Additionally, the number of T-bet+ cells and INF-γ expression were found to be inversely correlated with degree of H. pylori density and chronic inflammation score (CIS) in infected patients with gastritis disease, but this correlation was positive in the infected patients with PUD. The number of T-bet+ cells was found to be positively correlated with the number of Th17 cells and inversely correlated with the number of Treg cells in infected patients with gastritis and PUD. Conclusion Abnormal hyper-activation of T-bet+ cells during H. pylori-infection may lead to tissue damage caused by immunopathologic reactions. |
| Databáze: | OpenAIRE |
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