| Autor: |
Damiano Panelli, Francesco Papa, Francesca Paola Lorusso, Sergio Papa, Anna Maria Sardanelli |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Journal of Bioanalysis & Biomedicine. |
| ISSN: |
1948-593X |
| DOI: |
10.4172/1948-593x.s3-006 |
| Popis: |
In mammals, complex-I (NADH-ubiquinone oxidoreductase) of the mitochondrial respiratory chain has 31 supernumerary subunits in addition to the 14 conserved from prokaryotes to humans. Multiplicity of structural protein components, as well as of biogenesis factors, make complex-I a sensible pace-maker of mitochondrial respiration. The work reviewed here shows that the Alternative Splicing and Nonsense Mediated Decay pathways regulate the transcription products of different nuclear genes encoding subunits of complex I. Complex-I dysfunction has been found to be associated with several human diseases. Involvement of altered pattern of transcription products of complex-I genes in pathogenetic mechanisms of these diseases is examined. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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