In vitro activities ofCedrela tubiflora aqueous leaf extracts on murine macrophages, polymorphonuclear leukocytes and complement

Autor:	F.C. Coulombié, Maria C. Courreges, Fabián Benencia
Rok vydání:	1996
Předmět:	Pharmacology Phagocyte Phagocytosis Biological activity Metabolism Biology Molecular biology In vitro Respiratory burst medicine.anatomical_structure Immune system Biochemistry medicine Macrophage
Zdroj:	Phytotherapy Research. 10:37-41
ISSN:	1099-1573 0951-418X
DOI:	10.1002/(sici)1099-1573(199602)10:1<37::aid-ptr770>3.0.co;2-z
Popis:	Cedrela tubiflora aqueous leaf extracts are capable of inhibiting in vitro the activity of some components of the mouse immune system related to inflammatory responses. A significant reduction in the phagocytic capability and respiratory burst response (61.5% and 57.6%, respectively) of murine peritoneal macrophages was observed when these cells were incubated for 24 h with medium containing 1 mg/mL extract. On the other hand, at a concentration of 4 mg/mL, the extract reduced significantly the phagocytic activity of mouse polymorphonuclear leukocytes (87.5%) without altering the oxidative metabolism of these cells. Finally, a concentration of 2 mg/mL was required to inhibit the haemolytic activity of both pathways of mouse complement.
Databáze:	OpenAIRE
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