Erosive pustular dermatosis of the leg: Long-term control with topical tacrolimus

Autor:	Giampiero Girolomoni, Elena Dall’Olio, Paolo Rosina
Rok vydání:	2011
Předmět:	medicine.medical_specialty integumentary system business.industry Dermatology Topical tacrolimus Pustulosis Erosive pustular dermatosis Tacrolimus medicine.anatomical_structure Close relationship Scalp Medicine Clobetasol propionate medicine.symptom business Long term control medicine.drug
Zdroj:	Australasian Journal of Dermatology. 52:e15-e17
ISSN:	0004-8380
DOI:	10.1111/j.1440-0960.2009.00584.x
Popis:	Erosive pustular dermatosis of the leg is an unusual form of sterile pustulosis that typically affects the lower limbs of elderly patients. We report the cases of two women who developed erythematous skin plaques with pustules that coalesced and evolved into erosions and crusted areas. Histology showed epidermal spongiosis with subcorneal pustules and a dermal infiltrate with eosinophils and neutrophils. Lesions were treated with topical clobetasol propionate 0.05% for 10 days followed by topical tacrolimus daily until complete resolution, and then twice weekly for 1 year, without relapse. The response to topical corticosteroids and tacrolimus further support the close relationship with erosive pustular dermatosis of the scalp. Topical therapy with tacrolimus may offer good long-term disease control.
Databáze:	OpenAIRE
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