Surface-enhanced resonance Raman and circular dichroism spectra of amphotericin B and its methylester derivative in silver colloidal solutions

Autor:	J. Aubard, Yara Ridente, Jacques Bolard
Rok vydání:	1998
Předmět:	Liposome Circular dichroism Chemistry Stereochemistry Bilayer Chemical structure Polyene Combinatorial chemistry General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Mechanism of action Amphotericin B medicine medicine.symptom Derivative (chemistry) medicine.drug
Zdroj:	Biospectroscopy. 2:1-8
ISSN:	1520-6343 1075-4261
DOI:	10.1002/(sici)1520-6343(1996)2:1<1::aid-bspy1>3.0.co;2-e
Popis:	Amphotericin B (AmB) is a macrolide polyene antibiotic with an asymmetrical distribution of hydrophobic and hydrophilic groups (Fig. 1). Due to this chemical structure AmB is poorly soluble water as well as in many organic solvent [1]. Amphotericin B is the most potent and effective clinically available drug for treating systemics fungal infections. This antibiotic exhibits a high toxicity. Numerous studies are currently being developed to modify its biodisponibility by liposomal delivery, in order to decrease its toxicity. To this approach, optical spectroscopies appear useful in the study of its mechanism of action. However, these spectroscopies give little information concerning the structure and orientation of AmB with respect to phospholipidic bilayer.
Databáze:	OpenAIRE
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