A practical synthesis of the [(2R)-3-(morpholinocarbonyl)-2-(1-naphthylmethyl)propionyl]-L-histidine moiety (P4-P2) in renin inhibitors

Autor:	Atsushi Tsubaki, Toshiaki Yamaguchi, Tetsuhide Kamijo, Akira Iyobe, Kinji Iizuka, Yoshiaki Kiso, Hiromu Harada, Katsuyuki Ogura
Rok vydání:	1990
Předmět:	Bicyclic molecule Chemistry medicine.drug_class Stereochemistry Organic Chemistry Renin–angiotensin system medicine Absolute configuration Moiety Carboxamide Histidine
Zdroj:	The Journal of Organic Chemistry. 55:1679-1682
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo00292a052
Popis:	We describe a convenient and practical method for synthesizing N-[(2R)-3-(morpholinocarbonyl)-2-(1-naphthylmethyl) propionyl]-L-histidine methyl ester, which is useful as a common precursor (P 4 -P 2 moiety) for the syntheses of renin inhibitors
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::990c3ae10f5589f49a9c70e426d18764 https://doi.org/10.1021/jo00292a052 Zobrazit plný text záznamu