Influence of microscopic malignant peritoneal mesothelioma on posttreatment survival
| Autor: | Robert N. Taub, John A. Chabot, Michael D. Kluger, M. Hesdorffer, C. M. DeRosa |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Journal of Clinical Oncology. 27:e15534-e15534 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2009.27.15_suppl.e15534 |
| Popis: | e15534 Background: Progression of malignant peritoneal mesothelioma to clinically evident disease is poorly understood. Operative cytoreduction and post-operative intraperitoneal chemotherapy, followed by a second operative cytoreduction with heated intraoperative intraperitoneal chemotherapy is protocol at Columbia University. Our ability to assess presence of microscopic disease at a unique second operation provides in vivo insight into disease progression. Methods: Operative, pathology and oncologist records were reviewed for 98 consecutive patients with peritoneal mesothelioma treated between 5/95 and 1/08. Microscopic disease was defined as positive pathology on random biopsies in the absence of gross disease at second operation, and disease-free as absence of gross and microscopic disease. Survival was defined as time from first operation to death or last follow-up. Survival and recurrence were compared using the Kaplan Meier and log-rank methods, and correlations by Fisher's exact method. Results: 98 first and 69 second operations were performed. Patients were 59% male, 88% Caucasian and mean age was 52. At the second operation, 38 had gross disease, 23 were disease-free and 8 had microscopic disease. Median follow-up was 21 months, median overall survival was 48 months, and median survival for the epithelial subtype was 64 months. There was no significant difference in survival between disease- free and microscopic pathologies (log-rank p No significant financial relationships to disclose. |
| Databáze: | OpenAIRE |
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