| Popis: |
The percutaneous invasion of microorganisms through damaged skin layers can lead to the onset of infections with potentially life-threatening complications, especially in vulnerable populations like newborns, elderly, and diabetic patients. With the emergence of superbugs that are resistant to almost all the available antibiotics and the unfruitful discovery of new antimicrobial compounds in the last few decades, there is a demand for novel engineering strategies to approach skin and soft tissue infections associated with the used of biomaterials. Naturally occurring anti-biofouling and antimicrobial interfaces based on spatial structure offer an unprecedented opportunity for biomaterial design, as they do not contribute to bacterial resistance, do not pollute the environment, and can be easily implemented in a variety of biomaterial interfaces. In this article, we review the complications caused by biomaterials in contact with the skin, especially those that compromise medical adhesives, sutures, and wound dressing materials. Then, we introduced bioinspired designs that can be implemented in those materials based on nano- and microscale topographies. |
